@article{Braid_2019, title={Does intra-articular injection of antimicrobials alongside corticosteroids or other medications reduce the risk of synovial sepsis?}, volume={4}, url={https://veterinaryevidence.org/index.php/ve/article/view/194}, DOI={10.18849/ve.v4i4.194}, abstractNote={<p><strong>PICO question</strong></p> <p>In horses, does treatment with intra-articular antimicrobials concurrently with intra-articular corticosteroids reduce the risk of iatrogenic synovial sepsis compared to intra-articular corticosteroids alone?</p> <p><strong>Clinical bottom line</strong></p> <p>From the current literature, there is no evidence showing that intra-articular injection of antibiotics in conjunction with corticosteroids reduces the risk of synovial sepsis. However, the intra-articular injection of polysulphated glycosaminoglycans (PSGAGs) in combination with corticosteroids was noted as a risk factor for developing iatrogenic synovial sepsis and therefore concurrent antibiotic injection when administering PSGAGs may be warranted. The reported frequency of infection following intra-articular injections was very low (0.02–0.08%).  An overall prevalence of iatrogenic synovial sepsis following all intra-articular injections based on data from all included studies was calculated as 0.02% (CI 0.02–0.03%). However, due to the paucity of literature on the topic, further studies are required in this field to determine more accurate clinical recommendations.</p> <p><img src="https://www.veterinaryevidence.org/rcvskmod/icons/oa-icon.jpg" alt="Open Access"> <img src="https://www.veterinaryevidence.org/rcvskmod/icons/pr-icon.jpg" alt="Peer Reviewed"></p>}, number={4}, journal={Veterinary Evidence}, author={Braid, Helen R}, year={2019}, month={Oct.} }