DOI
https://doi.org/10.18849/ve.v2i3.67Abstract
Clinical bottom line
There is currently no evidence to show that alpha-casozepine is effective as an anxiolytic when administered to dogs shortly (minutes to a few days) before exposure to an anxiety provoking stressor. There is limited and weak evidence to suggest that it may have a role to play in reducing anxiety in dogs over the medium to longer term but the available evidence is of low quality and / or high risk of bias, with confounding variables providing alternative explanations for the findings. More research is needed in this area.
References
Beata, C. et al. (2007) Effects of alpha-casozepine (Zylkene) versus selegiline hydrochloride (Selgian, Anipryl) on anxiety disorders in dogs. Journal of Veterinary Behaviour: Clinical Applications and Research, 2 (5), pp. 175-183 http://dx.doi.org/10.1016/j.jveb.2007.08.001
Kato, M. et al. (2012) Effects of prescription diet on dealing with stressful situations and performance of anxiety-related behaviors in privately owned anxious dogs. Journal of Veterinary Behavior: Clinical Applications and Research, 7 (1), pp. 21-26 http://dx.doi.org/10.1016/j.jveb.2011.05.025
Pageat, P. (1995) Pathologie du comportement du chien. Editions du Point Veterinaire, Maisons-Alfort: 208 – 224
Palestrini, C. et al (2010) Efficacy of a diet containing caseinate hydrolysate on signs of stress in dogs. Journal of Veterinary Behavior, 5 (6), pp. 309-317 http://dx.doi.org/10.1016/j.jveb.2010.04.004
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