Which Antibacterial Agent Performs Best for the Treatment and Clearance of Chlamydophila Felis Infection in Cats?

  • David Mills RSPCA Putney Animal Hospital 6 Clarendon Drive London SW15 1AA

Published:

2017-03-07

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DOI

https://doi.org/10.18849/ve.v2i1.55

Abstract

Clinical bottom line:

Based on the current evidence, oral doxycycline (10mg/kg PO q24h or 5mg/kg PO q12h) for at least 21 days represents the most efficacious treatment, both in terms of clinical improvement and permanent clearance of Chlamydophila felis infection in cats. In chronic infections, or where the duration of disease is unknown, a longer treatment course of 28 days is indicated. There is limited evidence that co-amoxiclav (12.5-22.5mg/kg q12h PO) may be used as an alternative, though a treatment period of at least 30 days is required.


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References

Dean, R. et al. (2005) Use of Quantitative Real-time Pcr to Monitor the Response of Chlamydophila Felis Infection to Doxycycline Treatment. Journal of Clinical Microbiology, 43 (4), pp. 1858–1864. DOI: http://dx.doi.org/10.1128/JCM.43.4.1858-1864.2005

Gerhardt, N. et al. (2006) Pharmacokinetics of Enrofloxacin and Its Efficacy in Comparison With Doxycycline in the Treatment of Chlamydophila Felis Infection in Cats With Conjunctivitis. Veterinary Record, 159 (18), PP. 591–594. DOI: http://dx.doi.org/10.1136/vr.159.18.591

German, A. et al. (2005) Oesophageal Strictures in Cats Associated With Doxycycline Therapy. Journal of Feline Medicine and Surgery, 7 (1), PP. 33–41. DOI: http://dx.doi.org/10.1016/j.jfms.2004.04.001

Hartmann, A. et al. (2010) Detection of Bacterial and Viral Organisms From the Conjunctiva of Cats With Conjunctivitis and Upper Respiratory Tract Disease. Journal of Feline Medicine and Surgery, 12 (10), pp. 775–82. DOI: http://dx.doi.org/10.1016/j.jfms.2010.06.001

Hartmann, A. et al. (2008). Efficacy of Pradofloxacin in Cats With Feline Upper Respiratory Tract Disease Due to Chlamydophila Felis or Mycoplasma Infections. Journal of Veterinary Internal Medicine, 22, 44–52. DOI: http://dx.doi.org/10.1111/j.1939-1676.2007.0012.x

Krakauer, T., Buckley, M. (2003). Doxycycline Is Anti-inflammatory and Inhibits Staphylococcal Exotoxin-induced Cytokines and Chemokines. Antimicrobial agents and chemotherapy, 47 (11), pp. 3630–3. DOI: http://dx.doi.org/10.1128/AAC.47.11.3630-3633.2003

McGrotty, Y. and Knottenbelt, C. (2002) Oesophageal Stricture in a Cat Due to Oral Administration of Tetracyclines. The Journal of Small Animal Practice, 43 (5), pp. 221–3. http://dx.doi.org/10.1111/j.1748-5827.2002.tb00062.x

Owen, W. et al. (2003) Efficacy of Azithromycin for the Treatment of Feline Chlamydophilosis. Journal of Feline Medicine and Surgery, 5(6), 305–11. DOI: http://dx.doi.org/10.1016/S1098-612X(03)00072-X

Ploneczka-Janeczko, K. et al. (2015) Reduction of Chlamydophila-felis-associated Signs by Roxithromycin Treatment Regimen in Cats Showing Doxycycline Intolerance. Veterinarni Medicina, 60 (11), PP. 654–661. DOI: http://dx.doi.org/10.17221/8534-VETMED

Schulz, B. Wolf, G. and Hartmann, K. (2006) Bacteriological and Antibiotic Sensitivity Test Results in 271 Cats With Respiratory Tract Infections. Veterinary Record, 158, pp. 269-270. DOI: http://dx.doi.org/10.1136/vr.158.8.269

Schulz, B. et al. (2013) Side Effects Suspected to Be Related to Doxycycline Use in Cats. Veterinary Record, 172, pp. 184–185. DOI: http://dx.doi.org/10.1136/vr.101031

Sparkes, A. et al. (1999) The Clinical Efficacy of Topical and Systemic Therapy for the Treatment of Feline Ocular Chlamydiosis. Journal of Feline Medicine and Surgery, 1 (1), pp. 31–35. DOI: http://dx.doi.org/10.1016/S1098-612X(99)90007-4

Sturgess, C. (2001) Controlled Study of the Efficacy of Clavulanic Acid-potentiated Amoxycillin in the Treatment of Chlamydia Psittaci in Cats. Veterinary Record, 149, pp. 73–76. DOI: http://dx.doi.org/10.1136/vr.149.3.73

Sykes, J. (1999) Comparison of the Polymerase Chain Reaction and Culture for the Detection of Feline Chlamydia Psittaci in Untreated and Doxycycline-treated Experimentally Infected Cats. Journal of Veterinary Internal Medicine, 13, pp. 146–52. DOI: http://dx.doi.org/10.1111/j.1939-1676.1999.tb02171

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Vol. 2 No. 1 (2017): The first issue of 2017

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /