Evidence Supporting Intralesional Stem Cell Therapy to Improve Equine Flexor Tendon Healing

  • Sushmitha Durgam Department of Veterinary Clinical Medicine University of Illinois 1008W Hazelwood Dr Urbana IL 61802
  • Matthew Stewart Department of Veterinary Clinical Medicine University of Illinois 1008W Hazelwood Dr Urbana IL 61802

Published:

2017-01-03

Share
Open Access Logo

DOI

https://doi.org/10.18849/ve.v2i1.50

Abstract

Clinical bottom line

Current experimental evidence suggests that intralesional stem cell administration improves the histological characteristics and matrix organisation of healing equine superficial digital flexor tendons (SDFT); however, the clinical relevance of these findings are not clear. Current case-based evidence suggests that cell-based therapies improve the quality of tendon healing and reduce the recurrence rates of SDFT injuries but the lack of any randomised, controlled prospective studies with function-based outcomes is still concerning, given the widespread advocacy for and use of ‘stem cell’ therapies for the treatment of equine tendon injuries.

 

Open Access Peer Reviewed

Author Biographies

Sushmitha Durgam, Department of Veterinary Clinical Medicine University of Illinois 1008W Hazelwood Dr Urbana IL 61802

Graduate student

Veterinary Clinical Medicine

Matthew Stewart, Department of Veterinary Clinical Medicine University of Illinois 1008W Hazelwood Dr Urbana IL 61802

Associate Professor

Veterinary Clinical Medicine

References

Caniglia, C.J. et al (2012) The Effect of Intralesional Injection of Bone Marrow Derived Mesenchymal Stem Cells and Bone Marrow Supernatant on Collagen Fibril Size in a Surgical Model of Equine Superficial Digital Flexor Tendonitis. Equine Veterinary Journal, 44 (4), pp. 587-593. http://dx.doi.org/10.1111/j.2042-3306.2011.00514.x

Crovace, A. et al (2007) Cell Therapy for Tendon Repair in Horses: An Experimental Study. Veterinary Research Communications, 31 (S1), pp. 281-283. http://dx.doi.org/10.1007/s11259-007-0047-y

Crovace, A. et al (2010) Histological and Immunohistochemical Evaluation of Autologous Cultured Bone Marrow Mesenchymal Stem Cells and Bone Marrow Mononucleated Cells in Collagenase-Induced Tendinitis of Equine Superficial Digital Flexor Tendon. Veterinary Medicine International, 2010, Article ID 250978. http://dx.doi.org/10.4061/2010/250978

Del Bue, M. et al (2008) Equine Adipose-Tissue Derived Mesenchymal Stem Cells and Platelet Concentrates: Their Association in Vitro and in Vivo. Veterinary Research Communications, 32 (S2), pp. 51-55. http://dx.doi.org/10.1007/s11259-008-9093-3

Durgam, S.S. et al (2016) Tendon-Derived Progenitor Cells Improve Healing of Collagenase-Induced Flexor Tendinitis. Journal of Orthopaedic Research, doi: 10.1002/jor.23251, [Epub ahead of print]. http://dx.doi.org/10.1002/jor.23251

Godwin, E.E. et al (2012) Implantation of Bone Marrow-Derived Mesenchymal Stem Cells Demonstrates Improved Outcome in Horses with Overstrain Injury of the Superficial Digital Flexor Tendon. Equine Veterinary Journal, 44 (1), pp. 25-32. http://dx.doi.org/10.1111/j.2042-3306.2011.00363.x

Guest, D. et al (2010) Equine embryonic stem-like cells and mesenchymal stromal cells have different migration patterns following their injection into damaged superficial digital flexor tendon. Equine Veterinary Journal, 42 (6), pp. 636-642. http://dx.doi.org/10.1111/j.2042-3306.2010.00112.x

Lange-Consiglio, A. et al A (2013) Conditioned Medium from Horse Amniotic Membrane-Derived Multipotent Progenitor Cells: Immunomodulatory Activity in Vitro and First Clinical Application in Tendon and Ligament Injuries in Vivo. Stem Cells and Development, 22 (22), pp. 3015-3024. http://dx.doi.org/10.1089/scd.2013.0214

Lange-Consiglio, A. et al B (2013) Investigating the Efficacy of Amnion-Derived Compared with Bone Marrow-Derived Mesenchymal Stromal Cells in Equine Tendon and Ligament Injuries. Cytotherapy, 15 (8), pp. 1011-1020. http://dx.doi.org/10.1016/j.jcyt.2013.03.002

Lacitignola, L. et al (2008) Cell Therapy for Tendinitis, Experimental and Clinical Report. Veterinary Research Communications, 32 (Suppl 1), pp. S33-S38. http://dx.doi.org/10.1007/s11259-008-9085-3

Marfe, G. et al. (2012) A New Clinical Approach: Use of Blood-Derived Stem Cells (BDSCs) for Superficial Digital Flexor Tendon Injuries in Horses. Life Sciences, 90, pp. 825-830. http://dx.doi.org/10.1016/j.lfs.2012.03.004

Nixon, A.J. et al (2008) Effect of Adipose-Derived Nucleated Cell Fraction on Tendon Repair in Horses with Collagenase-Induced Tendinitis. American Journal of Veterinary Research, 69 (7), pp.928-937. http://dx.doi.org/10.2460/ajvr.69.7.928

Schnabel, L.V. et al (2009) Mesenchymal Stem Cells and Insulin-Like Growth Factor-I Gene Enhanced Mesenchymal Stem Cells Improve Structural Aspects of Healing in Equine Flexor Digitorum Superficialis Tendons. Journal of Orthopaedic Research, 27 (8), pp. 1392-1398. http://dx.doi.org/10.1002/jor.20887

Smith, R.K. et al (2003) Isolation and Implantation of Autologous Equine Mesenchymal Stem Cells from Bone Marrow into the Superficial Digital Flexor Tendon as a Potential Novel Treatment. Equine Veterinary Journal, 35 (1), pp. 99-102. http://dx.doi.org/10.2746/042516403775467388

Smith, R.K.W. et al (2013) Beneficial Effects of Autologous Bone Marrow-Derived Mesenchymal Stem Cells in Naturally Occurring Tendinopathy. PLosOne, 8 (9), e75697. http://dx.doi.org/10.1371/journal.pone.0075697

Sole, A. et al (2013) Distribution and Persistence of Technetium-99 Hexamethyl Propylene Amine Oxime-Labelled Bone Marrow-Derived Mesenchymal Stem Cells in Experimentally Induced Tendon Lesions after Intratendinous Injection and Regional Perfusion of the Equine Distal Limb. Equine Veterinary Journal, 45 (6), pp. 726-731. http://dx.doi.org/10.1111/evj.12063

Watts, A.E. et al (2011) Fetal Derived Embryonic-Like Stem Cells Improve Healing in a Large Animal Flexor Tendonitis Model. Stem Cell Research and Therapy, 2 (4), pp. 1-12.

2,759

Save

2,901

View

Vol. 2 No. 1 (2017): The first issue of 2017

Section: Knowledge Summaries

Categories :  Small Animal  /  Dogs  /  Cats  /  Rabbits  /  Production Animal  /  Cattle  /  Sheep  /  Pig  /  Equine  /  Exotics  /