Dairy cow

In Dairy Cows with Clinical Mastitis Do Systemic Antimicrobials in Addition to Intramammary Antimicrobials Improve Clinical Cure Rates Compared to Intramammary Antimicrobials Only?

Matthew Barden

Published:  04/10/2016    in:  Knowledge Summaries
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Dairy cow
Abstract

Clinical bottom line

In spite of limitations to the available studies, in cattle with clinical mastitis and an absence of systemic signs there is no evidence that combined systemic and intramammary antimicrobial therapy improves clinical cure rates compared to intramammary antimicrobial therapy only.

In two studies, cattle with severe coliform mastitis showed improved clinical parameters following combined systemic and intramammary antimicrobial therapy compared to intramammary antimicrobial therapy only. 


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References

  1. Erskine, R.J. et al (2002) Efficacy of Systemic Ceftiofur as a Therapy for Severe Clinical Mastitis in Dairy Cattle. Journal of Dairy Science, 85 (10) pp. 2571-2575. http://dx.doi.org/10.3168/jds.S0022-0302(02)74340-3
  2. Hillerton, J.E. and Kliem, K.E. (2002) Effective Treatment of Streptococcus uberis Clinical Mastitis to Minimize the Use of Antibiotics. Journal of Dairy Science, 85 (4) pp. 1009-1014.
  3. Shipgel, N.Y. et al (1997) Efficacy of Cefquinome for Treatment of Cows with Mastitis Experimentally Induced using Escherichia coli. Journal of Dairy Science, 80 (2) pp. 318-323. http://dx.doi.org/10.3168/jds.S0022-0302(97)75941-1
  4. Swinkels, J.M. et al (2013) Effect of Extended Cefquinome Treatment on Clinical Persistence or Recurrence of Environmental Clinical Mastitis. The Veterinary Journal, 197 (3) pp. 682-687. http://dx.doi.org/10.1016/j.tvjl.2013.03.010
  5. Wenz, J.R. et al (2005) Short Communication: Efficacy of Perenteral Ceftiofur for Treatment of Systemically Mild Clinical Mastitis in Dairy Cattle. Journal of Dairy Science, 88 (10) pp. 3496-3499. http://dx.doi.org/10.3168/jds.S0022-0302(05)73034-4


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