Dairy cow

Does Heat Stress Affect Immune Function in Dairy Cows?

Mike Steele

Published:  14/09/2016    in:  Knowledge Summaries
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Dairy cow

Clinical bottom line

Heat stress appears to generally suppress innate immune function in both dry and lactating dairy cows. Immune effects that are decreased include cytokine production, proliferation of immune cells, migration of lymphocytes to the udder and cell viability. This may lead to an increase in the risk of clinical diseases such as mastitis and metritis. 

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  1. Baumgard, L.H, and Rhoads, R.P. (2013) Effects of Heat Stress on Postabsorptive Metabolism and Energetics. Annual Reviews in Animal Biosciences, 1 (1), pp. 311-337. http://dx.doi.org/10.1146/annurev-animal-031412-103644
  2. Bernabucci, U. et al. (2014) The Effects of Heat Stress in Italian Holstein Dairy Cattle. Journal of Dairy Science, 97 (1), pp. 471-486. http://dx.doi.org/10.3168/jds.2013-6611
  3. Collier, R.J. et al. (2008) Invited Review: Genes Involved in the Bovine Heat Stress Response. Journal of Dairy Science, 91 (2), pp. 445-454. http://dx.doi.org/10.3168/jds.2007-0540
  4. Do Amaral, B.C. et al. (2010) Heat Stress Abatement during the Dry Period Influences Prolactin Signaling in Lymphocytes. Domestic animal endocrinology, 38 (1), pp. 38-45. http://dx.doi.org/10.1016/j.domaniend.2009.07.005
  5. Do Amaral B.C. et al. (2011) Heat Stress Abatement during the Dry Period Influences Metabolic Gene Expression and Improves Immune Status in the Transition Period of Dairy Cows. Journal of Dairy Science, 94 (1), pp. 86-96. http://dx.doi.org/10.3168/jds.2009-3004
  6. Elvinger, F. Hansen, P.J. and Natzke, R.P. (1991) Modulation of Function of Bovine Polymorphonuclear Leukocytes and Lymphocytes by High Temperature in Vitro and in Vivo. American Journal of Veterinary Research, 52 (10), pp. 1692-1798.
  7. Elvinger, F. Natzke, R.P, and Hansen, P.J. (1992) Interactions of Heat Stress and Bovine Somatotropin Affecting Physiology and Immunology of Lactating Cows. Journal of Dairy Science, 75 (2), pp. 449-462. http://dx.doi.org/10.3168/jds.S0022-0302(92)77781-9
  8. Kamwanja, L.A. et al. (1994) Responses of Bovine Lymphocytes to Heat Shock as Modified by Breed and Antioxidant Status. Journal of Animal Science, 72 (2) pp. 438-444.
  9. Kehrli, M.E. Nonnecke, B.J. and Roth, J.A. (1989) Alterations in Bovine Neutrophil Function during the Periparturient Period. American Journal of Veterinary Research, 50 (2) , pp. 207-214.
  10. Lacetera, N. et al. (2002) Moderate Summer Heat Stress Does Not Modify Immunological Parameters of Holstein Dairy Cows. International Journal of Biometeorology 46, no. 1 (2002): 33-37. http://dx.doi.org/10.1007/s00484-001-0115-x
  11. Lacetera, N. et al. (2006) Heat Stress Elicits Different Responses in Peripheral Blood Mononuclear Cells from Brown Swiss and Holstein Cows. Journal of Dairy Science, 89 (12), pp. 4606-4612. http://dx.doi.org/10.3168/jds.S0022-0302(06)72510-3
  12. Lacetera, N. et al. (2005) Lymphocyte Functions in Dairy Cows in Hot Environment. International Journal of Biometeorology, 50 (2), pp. 105-110. http://dx.doi.org/10.1007/s00484-005-0273-3
  13. Thompson, I.M. (2014) Effect of Cooling during the Dry Period on Immune Response after Streptococcus Uberis Intramammary Infection Challenge of Dairy Cows. Journal of Dairy Science, 97 (12), pp. 7426-7436. http://dx.doi.org/10.3168/jds.2013-7621

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