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Can Cytosine Arabinoside With Prednisolone Treatment for Canine Meningoencephalitis of Unknown Origin Increase Survival Time Compared to Prednisolone Treatment Alone?

Christopher Stefan Francis Kozlowski Hoey, Christina Maunder

Published:  10/07/2018    in:  Knowledge Summaries
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Abstract
PICO question

In treatment of canine patients with meningoencephalitis of unknown origin (MUO), is combination therapy of cytosine arabinoside (CA) with prednisolone more effective than prednisolone as a sole therapy at increasing survival time?

Clinical bottom line

Based on current available evidence, cytosine arabinoside with prednisolone has greater median survival time than prednisolone as a sole therapy in dogs with meningoencephalitis of unknown origin. The evidence to support this is very weak, as there are currently a low number of published papers with a relatively small number of cases reported in these studies evaluating cytosine arabinoside with prednisolone or prednisolone as a sole therapy for treatment of meningoencephalitis of unknown origin.


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References

  1. Flegel, T., Boettcher, I., Matiasek, K., et al, 2011. Comparison of oral administration of lomustine and prednisolone or prednisolone alone as treatment for granulomatous meningoencephalomyelitis or necrotizing encephalitis in dogs. Journal of the American Veterinary Medical Association, 238(3), pp.337-345. http://dx.doi.org/10.2460/javma.238.3.337
  2. Lowrie, M., Thomson, S., Smith, P., et al, 2016. Effect of a constant rate infusion of cytosine arabinoside on mortality in dogs with meningoencephalitis of unknown origin. The Veterinary Journal, 213, pp.1-5. http://dx.doi.org/10.1016/j.tvjl.2016.03.026
  3. Lowrie, M., Smith, P. and Garosi, L., 2013. Meningoencephalitis of unknown origin: investigation of prognostic factors and outcome using a standard treatment protocol. Vet Rec, 172(20), p.527. http://dx.doi.org/10.1136/vr.101431
  4. Menaut, P., Landart, J., Behr, S., et al, 2008. Treatment of 11 dogs with meningoencephalomyelitis of unknown origin with a combination of prednisolone and cytosine arabinoside. Veterinary Record: Journal of the British Veterinary Association, 162(8). http://dx.doi.org/10.1136/vr.162.8.241
  5. Smith, P., Stalin, C., Shaw, D., et al, 2009. Comparison of two regimens for the treatment of meningoencephalomyelitis of unknown etiology. Journal of veterinary internal medicine, 23(3), pp.520-526.
  6. Zarfoss, M., Schatzberg, S., Venator, K., et al, 2006. Combined cytosine arabinoside and prednisone therapy for meningoencephalitis of unknown aetiology in 10 dogs. Journal of small animal practice, 47(10), pp.588-595.


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Copyright (c) 2018 Christopher Stefan Francis Kozlowski Hoey, Christina Maunder

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