Clinical bottom line
Based on the current available evidence, omeprazole is the superior choice for raising intra-gastric pH.
Bersenas, A.M.E. et al. (2005) Effects of ranitidine, famotidine, pantoprazole, and omeprazole on intragastric pH in dogs. American Journal of Veterinary Research, 66 (3), pp. 425-431 http://dx.doi.org/10.2460/ajvr.2005.66.425
Fallenius, E. et al. (1981) Substituted benzimidazoles inhibit gastric secretion by blocking H+/ K+- ATPase. Nature 29:159- 161 http://dx.doi.org/10.1038/290159a0
Fallenius, E. et al. (1982) Inhibition of acid secretion in isolated gastric glands by substituted benzimidazoles. American Journal of Physiology 243: G505- G510.
Katz, L.B.Tobia, A.J. and Shriver, D.A. (1987) Effects of ORF 17583, other histamine H2-receptor antagonists and omeprazole on gastric acid secretory states in rats and dogs. Journal of Pharmacology and Experimental Therapeutics, 242 (2), pp. 437-42.
Kromer, W. Postius, S. and Riedel, R. (2000) Animal Pharmacology of Reversible Antagonism of the Gastric Acid Pump, Compared to Standard Antisecretory Principles. Pharmacology, 60 (4), pp. 170-187 http://dx.doi.org/10.1159/000028367
Okabe, S. Shimosako, K. and Amagase, K. (2001) Pharmacological regulation of gastric acid secretion in the apical membrane of parietal cells; a new target for antisecretory drugs. Journal of Physiology and Pharmacology, 52 (4 Pt 1) pp. 639-56.
Polentarutti, B. et al. (2010) Modification of gastric pH in the fasted dog. Journal of Pharmacy and Pharmacology, 62 (4), 462-469 http://dx.doi.org/10.1211/jpp.62.04.0008
Stachura, J. et al. (1983) Comparison of the effect of omeprazole--a substituted benzimidazole--and ranitidine--a potent H2-receptor antagonist--on histamine-induced gastric acid secretion and the ultrastructure of canine parietal cells. Hepatogastroenterology, 30 (5), pp. 205-10.
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