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Which is More Effective in Altering the Intra-Gastric pH in Dogs, Omeprazole or Ranitidine?

Adam Swallow

Published:  05/05/2016    in:  Knowledge Summaries

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Clinical bottom line

Based on the current available evidence, omeprazole is the superior choice for raising intra-gastric pH.

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  3. Fallenius, E. et al. (1982) Inhibition of acid secretion in isolated gastric glands by substituted benzimidazoles. American Journal of Physiology 243: G505- G510. 
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  7. Polentarutti, B. et al. (2010) Modification of gastric pH in the fasted dog. Journal of Pharmacy and Pharmacology, 62 (4), 462-469 
  8. Stachura, J. et al. (1983) Comparison of the effect of omeprazole--a substituted benzimidazole--and ranitidine--a potent H2-receptor antagonist--on histamine-induced gastric acid secretion and the ultrastructure of canine parietal cells. Hepatogastroenterology, 30 (5), pp. 205-10.

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